• Recently Published Thyroid Research
• Thyroid Research Archive
• Clinical Research Projects

Thyroid Hormone Action

November 2006

• Triiodothyronine has rapid vasodilatory and neuroprotective actions

November 2004

• Thyronamines are naturally occurring metabolites of thyroid hormone that inhibit neural and cardiac function in animals

March 2002

1. Thyroid hormone stimulates bone growth by increasing the action of insulin-like growth factor-I
   

Thyroid Hormone Secretion

July 2006

• Deficiency of thyrotropin-releasing hormone impairs the thyrotropin response to hypothyroidism

July 2004

• Genetic factors are more important than environmental factors in determining pituitary–thyroid function in normal subjects

March 2004

• Megalin facilitates thyroid hormone secretion by removing thyroid hormone–poor thyroglobulin

Thyroid Hormone Therapy

July 2006

• Absorption of thyroxine is decreased in patients with gastric inflammation and by omeprazole therapy

March 2005

• Lean body mass is the major determinant of thyroxine dose in patients with hypothyroidism
  
  
• Triiodothyronine does not augment the effects of paroxetine in patients with depression

November 2003

• Raloxifene decreased the intestinal absorption of thyroxine in a patient with hypothyroidism

July 2003

• Hip fracture is not increased in older women treated with thyroid hormone

Thyroid Hormone Production

March 2006

• Genetic deficiency of type 3 iodothyronine deiodinase in mice results in fetal and neonatal hyperthyroidism followed by central hypothyroidism

November 2005

• Conversion of thyroxine to triiodothyronine outside the thyroid is mediated primarily by type 2 deiodinase